The Amanda Show is another series that was spun off of "All That" for another of its breakout stars. It's a skit show with some of the characteristics of "All That" but with different characters. In spite of being designed as a sketch comedy television program, the series is set in a fictional universe in which it also is broadcast as a popular television comedy as evidenced through staged mishaps with members of the viewing audience and performers featured the program and comedic sub-plots involving Amanda's unhealthily obsessed, nerdy, feckless self-proclaimed "Number One Fan" Penelope Taynt, who has prioritized devising schemes that will assist her in achieving her lifelong goal of meeting Amanda before all else and her multiple failed attempts at landing a meeting with the hostess of the series (as a gag, Amanda Bynes actually portrays Penelope in reality and the pair are never shown onscreen together). Such failed schemes may include Penelope's attempts at outsmarting the fictional security guard of the studio in which episodes of the Amanda Show are filmed and at manipulating Amanda's cast-mates into helping her carry out her plans.

Aside from this, the series is formatted as a typical sketch comedy performed by actors who play themselves in sub-plots for the program, a routine involving sketches featured in many other episodes as well as a few sketches only seen in one episode. Sketches included may be parodies (such as "Judge Trudy," an obvious spoof of Judge Judy, "So You Want to Win Five Dollars?", as a parody of Who Wants To Be a Millionaire?, and "Blockblister," a parody of the video rental shop Blockbuster that is known for its constant use of parodies of well-known movies) or shorts featuring humorously eccentric or dimwitted characters.