The Head is the story of Jim, a grade-school student, who awakens one morning to find that his cranium has enlarged to mammoth proportions. A week later, out bursts Roy, an little blue alien with an odd sense of humor, who's taken up residence in Jim's head. Turns out Roy needed a place to stay to adapt to the Earth's environment while on a mission to save the world from a power-hungry alien named Gork. Aiding Jim and Roy are his girlfriend, Madelyn, his doctor, Dr. Richard Axel, and a group of "human anomalies." The group consists of Ray, a landscaper who has a lawnmower blade lodged in his skull; Mona, a normal looking woman with a tail; Ivan, who has a mouth in his chest; Raquel, who has a nose like a rat; Earl, who has a fishbowl in his mouth; Chin, a long-limbed former-freak show performer; and the annoyingly normal head of the group, Shane Blackman.

After the initial 13 episodes had aired, "MTV's Oddities" began airing another serial, entitled The Maxx. When "The Maxx" had finished airing, "The Head" returned with a new batch of episodes, but the focus often shifted from Jim and Roy to the other "human anomalies" they'd befriended -- and the new episodes lacked the serial structure that had made the initial run so successful. Shortly after the second season finished airing, "The Head" (along with "MTV's Oddities") vanished from the airwaves.