Agent 11 is the name of a bullmastiff used by the FBI to fight crime. After the dog injures a man who is the leader of a mafia, he sends his bodyguards out to find and kill the dog. The dog is sent to an Alaska training camp for its protection. After the dog escapes, it is taken in by a family manned by mailman Gordon Smith, who hates dogs. The family names the dog Spot. The family soon teach Spot to play, and act like less of a crime fighter, and despite growing fond of him, he is still being hunted by the FBI and the mafia members who want him back, and dead.