This show is about a little goth girl named Lydia who isn't like her happy-faced school girl peers, and is sick of her tortured and boring life so she summons a freelance bio-exorcist ghost with the most named Beetlejuice! And her boring life soon becomes filled with fun and danger. Beetlejuice can shapeshift into anything and has a great sense of humor, he is wise cracking type of ghost. For example: One time Lydia enters the Neitherworld (Afterlife world filled with Beetlejuice and other ghosts, corpses, and monsters), she enters Beetlejuice's house and he is sitting in a barbers chair. Beetlejuice is getting his hair cut and says he needs some mouse. Then on the corner of his shoulder pops a small moose lathering up his hands and putting mouse in BJ's hair. Just about everything you can think of in the Neitherworld, lived up to its name. Like a monkey wrench would actually look like a monkey, or The Pat on the Back was an evil leprechaun that popped up on your back. Even his neighbor's dog was a cross between a bull and a dog.

He was disliked by the other ghouls and ghosts in the Netherworld, because of the pranks he played on them. Lydia would later get a car named Doomie, that would transform into a werebeast when cornered , threatened or when Lydia and Beetlejuice were in trouble. Lydia also had to put up with a snobby girl in school, but Beetlejuice always managed to get back at her in a pretty gross yet funny way.

The show was filled with good humor like that as well as great animation.