Drake Parker(Drake Bell) is a ladies man, rock star, and not very academically achieved. Josh Nichols(Josh Peck) is smart, funny, and not very popular. One day, Drake's stay-at-home mom Audrey(Nancy Sullivan) and Josh's dad, weatherman Walter(Jonathan Goldstien) announce they are marrying, and these two different boys are now bothers! They live together with their daily antics along with Drake's cunning trickster of a younger sister Megan(Miranda Cosgrove).