Pee-Wee Herman invites his audience friends to come play in his magical house with talking furniture, flying bicycles and occasional wacky guests. In case you did not know, Cyndi Lauper sings the theme song! Think Mr. Rogers with a zanier, more entertaining host and more colorful, more animated house features. Pee-Wee's Playhouse was the top rated children's show enjoyed by children and teens alike until it was abruptly cancelled due to Paul Reuben's arrest for public indecency.

After the show's sudden cancellation, the original episodes were shown on the Fox Family (now known as Freeform) channel from 1996-1999 as part of the Basement, a collection of cartoons and live-action shows that originated in the 1980's. In July of 2006, Pee-Wee's Playhouse has been showing on Cartoon Network's [adult swim] block of late-night programming. Currently the show has been playing at two different times: 12 a.m. and 3 a.m.