Pinky and the Brain, two genetically-enhanced lab mice, are still trying to take over the world. However, now that they've lost their headquarters at ACME Labs, they're operating from the home of the animal over-loving Elmyra. Now Pinky and the Brain must continually avoid Elmyra and a neighborhood bully. Add to that a secret organization trying to apprehend the Brain. Given all of the complications, Pinky and the Brain's plots usually fail before you can say, "TROZ! ZORT!"
On September 1, 1998, the series "Pinky and the Brain" was retooled to the much-reviled Pinky, Elmyra and the Brain, in which Pinky and the Brain were owned by Tiny Toons character Elmyra Duff, and is considered to be the reason for the show's cancellation. The show lasted for 13 episodes, 5 of which were shown whole and 6 of which were chopped into segments and aired as part of The Cat&Birdy Warneroonie PinkyBrainy Big Cartoonie Show.
The idea came directly from the Network executives, much to the dismay of the shows creator.