The series is about the Cuyler family, an impoverished family of anthropomorphic hillbilly mud squids living in the Georgia region of the Blue Ridge Mountains. The series revolves around the exploits of an alcoholic father (Early), who is often abusive in a comedic way towards his family. His son, Rusty, is desperate for his approval; his mother and grandmother, known in the show as Granny, is often the center of his aggression; and Lily, Early's sister, is mostly unconscious in a pool of her own vomit.