Rules: You can't say "blank" show beats them both. This is for FAMILY GUY VS SIMPSONS ONLY!!
That being said, The Simpsons are America's family (and Canada, im from there lol) and nobody will ever be able to replace or change cartoons like they did. No one cartoon character will ever be as funny as homer, his voice alone can never be replaced and the creative comedy behind the voice is amazing. The Simpsons are a classic and the original and will always all around be the best. ALWAYS! Argue their late season weren't as funny but all of Family Guy put together aren't as creative as the first few seasons. Not too mention I got tired of Guy's one line repetitive jokes after just a few seasons. Simpsons are STILL here and always will be :)
My choice: The Simpsons.
your turn :)