Guess with Jess is a British-Canadian-American interactive animated children's television series featuring Jess the Cat from the TV series Postman Pat. The show follows Jess's adventures with his friends on Greendale Farm in London, England, and how they always try to solve each other's problems with a Big Question, which is answered by "asking, testing, find a way". The series is an enquiry-based learning show aimed at two- to four-year-olds. Jess and his friends search for the answers to science and nature-based questions, allowing children to learn about the world around them. 52 episodes were produced.

Unlike his appearance in Postman Pat, Jess in this series has the ability to talk to his friends on the farm.