In the sequel to The Magic School Bus, the flagship Ms. Valerie Frizzle (now Professor Frizzle) retires from teaching and passes the keys of the Magic School Bus over to her younger sister, Ms. Fiona Frizzle, to embark on new adventures with her class. As they journey on their exciting new field-trips, they discover new locations, creatures, time periods and more to learn about the wonders of science, educating viewers along the way. Having gone back to her old school, Phoebe from the original series is replaced with the Native American Jyoti Kaur.