Gerald McRaney and Jameson Parker star as Rick and Andrew Jackson "A.J." Simon, brothers working as private detectives in San Diego. The show also stars WKRP's Tim Reid (Venus Flytrap) as police Detectove Marcel "Downtown" Brown and Mary Carver as Cecelia Simon, the mother of Rick and A.J.

Typical 80's action-detective content (lockpicking, shootouts, car chases, clever disguises), with its own quirky sense-of-humor and a slightly more family-oriented bent, focusing on the relationships between the brothers and their mother, in between nabbing bad guys.

Simon & Simon ran around the same time as Murder She Wrote and Magnum P.I. in most places and in fact, there is even a three-part crossover episode where characters from each show interacted with each other in some fashion.