A girl named Penny and her dog Bolt are the stars of a hit TV show called "Bolt", in which Bolt has various superpowers and must always save Penny from the evil plans of her arch nemesis, Doctor Calico. To gain extra realism, Bolt's trainers have trained him into believing that the TV show is real, and after he thinks Penny has really been kidnapped, tries to escape from his Hollywood set and falls into a box of styrofoam peanuts and gets shipped to New York City. In New York, he meets several animals who he becomes friends with and he discovers his super powers are not working, falsely assuming that styrofoam is his weakness. He now needs the help of his friends to get back to Hollywood and re-unite with Penny.