Inspired by the 1984 feature film, The further adventures of the Ghostbusters: Peter, Ray, Egon, Winston and Slimer as they seek to catch ghosts, protect New York City... and make money! They're ready to believe you!

The cartoon is titled "The Real Ghostbusters" as Filmation had already made a cartoon titled "Ghostbusters". In fact, the producers of the 1984 film had to buy the rights to the name.

Then in 1998, the show had a spinoff called "Extreme Ghostbusters." The show features the return of Egon from the original team who trains a new team of busters: Garret, Roland, Kylie, and Eduardo to combat ghosts once again with better weapons and a new ghost trap.