Charles Bigelow finds out his ex-wife,Margaret, has vanished while attending her mother's funeral. Charles travels to her hometown of Centerville only to find the town's weird residents (wearing 1950's clothing) who claim Margaret and her family never lived there. He discovers that the whole town has been taken over by aliens. Charles escapes but finds little help through the FBI (who is hiding a secret connection to the aliens). He finds help through a tabloid newspaper writer who might be able to help him slove the mystery behind Centerville.