a 13-episode anime television series, conceptualized by Type-Moon co-founders Kinoko Nasu and Takashi Takeuchi, based on the scenario that they created for the Wii visual novel 428: Shibuya Scramble, which is noted for being one of the few games to have been awarded a perfect score by games publication Famitsu. The series spawned manga and light novel adaptations.A sequel to the 428: Shibuya Scramble, it centers on three women and their connections to one-another and an upcoming anti-terrorism summit in Shanghai, China. One of them is Canaan, a Middle Eastern assassin and mercenary. Another is Alphard, Canaan's rival and also a skilled assassin and mercenary who heads a terrorist organization called Snake. The final girl is Maria Ōsawa, a victim of an attempted biological terrorist attack in the streets of Shibuya two years previous. Their encounters lead to armed interventions between Canaan and Alphard with a deep and tragic history in common.Two years after the events of 428: Shibuya Scramble, Maria Ōsawa and Minoru Minorikawa are dispatched as reporters to Shanghai in order to cover the upcoming Shanghai NBCR International Anti-Terrorist Conference. Prior to their current assignment, both Maria and Minoru were survivors of the Shibuya bio-terrorism incident, where Maria was kidnapped by terrorists and was infected by the Ua virus but was cured by her scientist father using an experimental anti-Ua virus vaccine. On her first day in Shanghai, Maria is targeted by masked assassins but saved by a Middle Eastern girl named Canaan, whom she befriended in the Middle East prior to the events of 428: Shibuya Scramble and her Shanghai trip.
Their presence in the city is being overshadowed by a mysterious event being planned by Alphard, Canaan's rival. Unknown to the two, Alphard is preparing a big plot related to the anti-terrorist summit after being rescued by Cummings and Liang Qi, a pair of mercenaries and Alphard's allies. Maria's life was placed in danger once mo