It has been 10 years since the last Killer Tomato has been squished into sauce. To this day the tasty red fruit are banned, and some folks fall in to paroxysms of fear at the mention of tomatoes. Still the general public has been lulled into believing that they are finally safe from the genetically engineered scourge. The purpose of this sci-fi sequel is to prove them wrong. The trouble begins when a pizza delivery boy (the pizzas only use non-tomato-base sauce) falls in love with a beautiful girl. Little does he know that she is the assistant of wicked Professor Gangreen who has engineered a brand new kind of tomato that can assume human form.