Frank is the zookeeper at the Sucat Memorial Zoo in Rhode Island with a very disgusting and unhealthy lifestyle. Despite his daughter, Shane's advice, he eats very unhealthily, and eats a hard boiled egg that had been dropped in a chimpanzee's feces. Inside his body, Osmosis Jones, a white blood cell who is determined for a little action, gets relocated to Frank's mouth to fight incoming germs. Soon, a virus named Thrax emerges from the egg Frank ate and plans to kill Frank with an infection posing as a common cold, with all the same symptoms. Frank's internal The Mayor is up for re-election, although a lot of his actions are responsible for Frank's deteriorating health. Frank winds up taking a cold pill named Drixenol, "Drix", who arrives inside his body and teams up with Ozzy. Ozzy and Drix must now team up to fight the infection before Frank slowly dies of it.
Starring the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Bradley Norwood, William Shatner, and Ron Howard, and the talents of Molly Shannon, Chris Elliott, Elena Franklin, and Bill Murray. Peter and Bobby Farrelly directs from the script by Marc Hyman; Animation Directed by Piet Kroon and Tom Sito. Produced by the Farrellys, Bradley Thomas, Zak Penn and Dennis Edwards. Music Composed and Conducted by Randy Edelman; Soundtrack on Warner Sunset/Atlantic, featuring songs from R. Thentic and De La Soul, Happy Roots, Fury, Craig David, Drama, Brandy, Trick Daddy featuring The Slip-N-Slide Express, Kid(ney) Rock featuring Joe C, DJ Spiller, Uncle Kracker, Solange, Control Freq, St. Lunatics, R. Kelly, Sunshine Anderson featuring Rayshawn Sherrer, and Debelah Morgan. A Conundrum Entertainment production for Warner Bros. Pictures.