There's been threads on this topic before but I thought I'd make a new one since I'm too lazy to find the older ones and because tastes and times change.

What are the upcoming games your looking forward to playing and what platform.

Huxley - An mmofps, pc version. I've always wanted a skill based mmo and I enjoy fps games, marriage of both makes it perfect. You could be level 100 and still get owned with someone who aims and has better skill than you at level 1. It would be harder for him but it can be done.
Age of Conan - Also the pc version, the game sounds cool. Differant combat system both melee and magic. You can create your own towns with guild housing and attack other with siege weaponry, like an rts in an mmo. Plus the fact that there's blood, hit detection so formations and territory matter, mounted combat and the M rating.
Spore - The idea of creating not only your own creature but your own civilization, planets, cities and all and than discovering other planets and their species and how they interact, it's the perfect sandbox.
Halo 3 - Many of you hate this game but I want to finish it. Xb360
Halo Wars - An rts on the Xbox? But it sounds and looks interesting and I've been itching for a good rts, starcraft 2 seems cool but I want something else.
Too Human - The more I read about it and see the vids, the more I think this game will be a winner, but you never know until it's released. This is for the 360 too.

Still waiting to get a wii until mariokart, animal crossing and final fantasy crystal chronicles 2 show up or is announced for it. There's also Lair and Uncharted: Drakes Territory that looks good for the PS3, but those games won't inspire me enough the dish out the cash, but if there's more games in the future, who knows? *shrugs*

I already have a Wii and right now I'm waiting for Metroid Prime 3, Super Smash Bros. Brawl, and Super Mario Galaxy. Nintendo has also been making the next Zelda game, for the Wii, for over a year.

For Xbox360, too many to count, but the ones that top my list right now are GTA IV, Halo 3, and Mass Effect.

For Wii, RE 4 and Manhunt 2 will be out soon. As for the rest of the year, MP 3 and Super Mario Galaxy. And Super Smash Bros. Brawl and Resident Evil: Umbrella Chronicles will be added it to the list if they do infact get release dates for this year.

Just announced/In production/coming very soon...
FF XIII Series
Metroid Prime: Corruption
Smash Bros. Brawl
Metal Gear Solid: GOTP
Ratchet & Clank: TOD
Devil May Cry 4
Alan Wake
Resident Evil:UC
Guitar Hero:RT80's & III
Uncharted: DF
God Of War III
Haze
The Darkness
BioShock
Alone In The Dark

and some that haven't been mentioned but may(or may not)/will come in the near future...
Twisted Metal
Onimusha

and many many more...