A paper cut-out show with a live action lead character named Steve. Steve lived with his puppy, Blue and figured out what Blue wanted to say through a trio of clues. The show set a standard format for kids shows to follow by having almost the exact same sequence of events occur at the same time every episode and an encouragement of viewer participation. The show had a unique art style with colorful paper cutout graphics resembling a storybook and a setting of a pretty plain house, being very familiar to children.

In 2002 Steve left the show to peruse a career in music and the show was taken over by his brother Joe(Donovan Patton). In 2006 a spin off named Blue's Room was made which featured Blue and other characters as puppets. To celebrate the 10th anniversary of that show the same year, Blue got a baby brother, a white puppy with rainbow-colored spots named Sprinkles.

Even today with almost all kids shows now following the format set by Blue's Clues, the impact this show had on children's television still remains relevant.

In 2019 Nickeloden announced a reboot called "Blue's Clues & You" that would be hosted by Joshua Dela Cruz.