El Mariachi just wants to play his guitar and carry on the family tradition. Unfortunately, the town he tries to find work in has another visitor...a killer who carries his guns in a guitar case. The drug lord and his henchmen mistake El Mariachi for the killer, Azul, and chase him around town trying to kill him and get his guitar case.

American crime lord Moco has set up a lucrative business in Mexico. He tries to rub out his imprisoned employee Azul. However, Azul overcomes the hit-men and escapes, determined to get his revenge. Meanwhile, a wandering mariachi comes to the same town looking for work. As Azul's trademark is his guitar case filled with weapons, the Mariachi is mistaken for him and finds himself a hunted man. Everyone looking for him likes to shoot first and ask questions later, so correcting the misunderstanding will not be easy.

El Mariachi just simply wants to play his guitar, no harm done, no questions asked. Unfortunately, he makes the mistake of attempting to find work in a local town, just when an assassin who keeps his guns in a guitar case hits town. El Mariachi is mistaken for the assassin. Not good.