Harley (Mickey Rourke) is a biker and his friend Marlboro (Don Johnson) is a modern-day cowboy. To help save a friend's bar, they rob the corrupt bank that wants to buy the bar as a location for their new building. Instead of getting money, they end up with a large quantity of a deadly new drug. Now the duo are on the run from both corrupt bankers and the drug dealers' henchmen. Fighting back is the only option, and it's the option they both choose.