Ruth Buzzi, who rose to fame as the frumpy and bitter Gladys Ormphby on the groundbreaking sketch comedy series “Rowan & Martin’s Laugh-In” and made over 200 television appearances during a 45-year career, has died at age 88.

Buzzi’s other recurring characters on “Laugh-In” included Flicker Farkle; Busy-Buzzi, a Hollywood gossip columnist; Doris Swizzler, a cocktail-lounge regular who got drunk with husband Leonard, played by Dick Martin; and an inconsiderate flight attendant.

Buzzi was a regular on the CBS variety show “The Entertainers,” whose hosts included Burnett and Bob Newhart.

She was in the original Broadway cast of “Sweet Charity” with Gwen Verdon in 1966.

Buzzi toured the country with her nightclub act, including appearances in Las Vegas.

She was a semi-regular on “That Girl” as Marlo Thomas’ friend. She costarred with Jim Nabors as time-traveling androids on “The Lost Saucer” in the mid-1970s.

Her other guest appearances included variety shows hosted by Burnett, Flip Wilson, Glen Campbell, Tony Orlando, Donny and Marie Osmond and Leslie Uggams.

She appeared in Ball’s last comedy series, “Life With Lucy.”

In the 1990s she played shopkeeper Ruthie, owner of the Finders Keepers thrift shop on "Sesame Street" as well as being the voice of the animated character Susie Kabloozie.

Buzzi guested in music videos with “Weird Al” Yankovic, the B-52’s and the Presidents of the United States of America.

She did hundreds of guest voices in cartoon series including “Pound Puppies,” “Berenstain Bears,” “The Smurfs” and “The Angry Beavers.”

She was Emmy nominated for her six-year run as shopkeeper Ruthie on “Sesame Street.”

Her movie credits included “Freaky Friday,” “Chu Chu and the Philly Flash,” “The North Avenue Irregulars” and “The Apple Dumpling Gang Rides Again.”