Bounty hunter Jack Walsh (Robert Deniro) has been assigned to a midnight run (a bounty hunting term meaning "a piece of cake"), his latest quarry is Jonathan Mardukas (Charles Grodin) a.k.a. The Duke. Mardukas is on the run for embezzling almost millions of dollars from the Mob and Walsh has been sent to bring Mardukas from New York to Chicago to Los Angeles. But when the Mob wants Mardukas dead, the FBI wants to arrest him,and Walsh's bounty hunting rival, Marvin Dorfler (John Ashton) wants to bring him in just for the money, chaos ensues in this fast-paced comedy/action-thriller/road movie/buddy movie that spawned the 3 made-for-TV sequels: Another Midnight Run, Midnight Runaround, & Midnight Run For Your Life, all starring Chris MacDonald (Shooter McGavin in "Happy Gilmore") in the role of Jack Walsh.