As the head of a highly specialized Behavioral Science unit within the U.S. Justice Department charge with the criminal profiling of unknown subjects, John Wesley Grayson (David Soul) is often called upon the uncover the hideous details of multiple-victim murders.

Members of the unit include an old-time Federal Agent (M. Emmet Walsh), a forensic scientist (Kent McCord), a doctor of psychology (Jennifer Hetrick), a team member who has the ability to get into the mind of the criminal (Joe Maruzzo), and the detail man (Richard Kind).