Dr. Richard Kimble, an Indiana pediatrician, is accused, arrested, tried and convicted of the murder of his wife. Kimble claims he was on his way home from a drive when the murder occurred, and saw a one-armed man running from his house upon his return. Kimble manages to escape from the detective assigned to the case, Lt. Philip Gerard, and spends the next four seasons on the run--helping people with their problems and searching for the one-armed man, while running before the relentless pursuit of the police detective obsessed with his capture--Gerard.