Jeff Daniels, Stanley Tucci, Cheryl Hines, and Andy Samberg lend their voices to this computer-animated comedy following the descendants of the first chimps in space as they blast off for fun and adventure on a far-away planet. Ham III (Samberg) is the grandson of Ham, the first-ever chimp astronaut. This ne'er-do-well chimp may not be the most qualified ape for the job, but a scheming senator (Tucci) has recruited him for a most dangerous mission. It seems that a powerful tyrant (Daniels) has overtaken an alien world, and now it's up to Ham III and his trusty simian crew (Hines and Patrick Warburton) to help overthrow the deep-space despot. Perhaps with some training from Ham III's mentor (Kenan Thompson) and the help of a friendly alien (Kristin Chenoweth) this fearless group of anthropoids can make the universe a safer place for aliens and humans alike.