Based on Warner Bros. Animation's 1993-98 show, the new incarnation of "Animaniacs" sees the return of the Warner Brothers (and their Sister) to the same old antics but now updated for the new age with references to modern age pop culture and society.

Also along for the ride are laboratory mice Pinky & the Brain, the duo with one mouse who is very smart and wants to take over the world and his friend who is incredibly dim-witted and always messes up his plan.