A few years after the events of the second film, both the government and the general public have become aware of the existence of the Vampires and Lycans. A program to study and potentially harness their powers soon escalates into an all-out genocide and shortly after the Purge begins, Selene and Michael are captured by humans. Due to her enhanced vampiric traits, Selene is imprisoned in cryogenic suspension. Later unfrozen she will be the one to lead humanity in the war against the vampires and Lycans.