First Take is an American sports talk show on ESPN. Episodes air daily Monday through Friday, with the live episode airing from 10am ET until noon, with reruns from 1:00 to 3:00 PM ET on ESPN2 and from 4:00 to 6:00PM ET on ESPNews

The show broadcast from Studio E at ESPN's headquarters in Bristol, Connecticut for its first eleven years, before the show moved to the network's new South Street Seaport facility on Pier 17 in September 2018 after Labor Day. It also has "roadshow" broadcasts for events such as the weeks of the College Football Playoff, the Super Bowl and the NBA Finals from the cities where those events take place.

Analysts and long-time sports reporters Max Kellerman and Stephen A. Smith (along with guests) are featured, with Molly Qerim acting as the show's moderator, introducing discussion topics. The two debate the topics with each other and the guests, along with providing occasional hot takes, about the sports news of the day.