A practical joker and career trouble maker named Heathcliff struts through life in search of new ways to torment Spike the neighborhood bulldog, or to woo his beloved fancy feline girlfriend Sonja.

At home, he is the bane of Grandpa's existence but adored by Grandma and Iggy Nutmeg, his human owners. Joined with Heathcliff is The Catillac Cats, a band of junkyard cats lead by their fearless leader Riff Raff and his girlfriend Cleo.

Their Cadillac that can change into almost anything from a trailer to a car all the way to a boat.

Riff Raff's get-rich-quick schemes and search for good eats have the rest of the gang (Hector, Mungo, and Wordsworth) constantly in and out of trouble and adventures.