Baby Herman swallows a rattle and is rushed to the hospital for surgery. Roger is shocked and sad about this. The rattle comes falling down into Roger's mouth after the baby burps it out after his milk break, and Roger swallows it. When the surgeon comes in to get Baby Herman ready for surgery, he thinks Roger is the patient that swallowed the rattle and much zany madness breaks loose.
Disney released Tummy Trouble in an effort to build up the Roger Rabbit character so he could be a draw in amusement parks and for merchandising. Paired with the feature Honey, I Shrunk the Kids, it took in $14 million (US) on opening weekend. It was the first cartoon short Disney had produced in 25 years to run with a feature film, since Goofy's Freeway Trouble in 1965. The short took 70 animators nine months to produce.
The hospital this short takes place at is "St. Nowhere", possibly an homage to the 1980s television show "St. Elsewhere".
The hospital doors Roger gets rushed through on his way to surgery include pathology, urology, proctology, gynecology, biology, radiology, geology, theology, archaeology, zoology, Egyptology, astrology, musicology, physiology, pharmacology, and phraseology, before he finally gets taken through one marked "Burbank".