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    Chicago-based daytime talk-show host Oprah Winfrey invites a guest panel to discuss a topic, in front of a studio audience. The topics are often controversial or sensational. In its 25 year run, the show became the most watched daytime talk show on television. In 2010 Oprah announced she would be ending the show to begin a full commitment to her channel OWN-The Oprah Winfrey Network. The last episode aired on May 25, 2011.