Robert Neville, a brilliant scientist, is a survivor of a man-made plague that transforms humans into bloodthirsty mutants. He wanders alone through New York City, calling out for other possible survivors, and works on finding a cure for the plague using his own immune blood. Neville knows he is badly outnumbered and the odds are against him, and all the while, the infected wait for him to make a mistake that will deliver Neville into their hands. Will Smith leads this post-apocalyptic thriller, opposite Alice Braga, and Dash Mihok. Francis Lawrence directs from the screenplay by Mark Protosevich and Akiva Goldsman; Based on the 1971 film 'The Omega Man', screenplay by John William & Joyce H. Corrington, and the 1954 Gold Medal novel of the same name by Richard Matheson. Produced by Goldsman, James Lassiter, David Heyman and Neal Moritz; Executive Produced by Michael Tadross, Erwin Stoff, Dana Goldberg, and Bruce Berman. A Weed Road/Overbrook Entertainment production for Warner Bros. Pictures, with Village Roadshow Pictures.