Because of George's tiny size, even mundane activities, such as working around the house or playing outside, often become dramatic adventures. His primary mode of transportation is his Zooper Car, a multi-purpose miniature vehicle he built with his father that can do things like transform into a submarine or a helicopter. George often has interesting encounters with animals who, although they do not talk, seem to be able to communicate with George throughout the series. On one occasion, he encountered a robotic alien that was his own size, and helped it get back home.

    The show affects a retro-1940s look, with simple animation and colors. Primarily jazz is used for background music, reflecting both his father's occupation as a musician who tinkers with inventing new musical instruments and his mother's style as an avant-garde artist. However, statements made in the characters' dialogue imply that events take place in the year 2000, or the year that the showing episode was produced and filmed.