Gaylord Myron "Greg" Focker and his fiancée Pam Byrnes decide to introduce their parents to each other. They first fly to Oyster Bay, Long Island, to pick up Pam's father, retired CIA operative Jack Byrnes, her mother Dina and one-year-old nephew Little Jack. But rather than going to the airport as planned, Jack decides to drive the family to Miami to meet the Fockers in his new RV. Once they arrive, they are greeted by Greg's eccentric but fun-loving and amiable father, Bernie, and mother, Roz, who is a sex therapist for elder couples. Worried that Jack may be put off by the Fockers' lifestyle, Greg convinces Roz to pretend that she is a yoga instructor for the weekend. Though Jack and Bernie get off to a good start, small cracks begin to form between Jack and the Fockers, due to their contrasting personalities. Things are made worse when a chase between the Fockers' dog, Moses, and the Byrns' cat, Jinx, culminates with Jinx flushing Moses down the RV's toilet, forcing Bernie to destroy it to save Moses, and later on when Bernie accidentally injures Jack's back during a game of football.