20 years after the events in Afghanistan, amid the political protests of the crisis in Burma, ruthless military officer Major Pa Tee Tint leads an army of Tatmadaw soldiers to pillage small villages in a campaign of fear. He watches with indifference as innocent villagers are forced into mine-infested marshes and orders his men to abduct the teenage boys of the villages to be drafted into his army. Former U.S. soldier John Rambo now lives in Thailand in a remote village near the Burmese border where he makes a living capturing and selling snakes as well as taxiing people up and down the Salween River in his boat. He is approached by missionary Michael Burnett who requests that he and his group be ferried into Burma on a humanitarian mission to provide aid to Karen tribespeople. Rambo refuses, claiming that without weapons, there will be no changes, but is eventually persuaded by missionary Sarah Miller to make the trip.