Set two years after the events of Spider-Man, the film finds Peter Parker struggling to manage both his personal life and his duties as Spider-Man, which affects his civilian life dramatically. Meanwhile, Dr. Otto Octavius becomes a diabolical villain after a failed experiment kills his wife and leaves him neurologically fused to mechanical tentacles. Spider-Man must stop him from successfully recreating the dangerous experiment, while dealing with a subconscious desire to stop being Spider-Man that is stripping him of his powers.
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