in a underwater research facility called Aquatica, a group of scientist hoping to find a cure for Alzheimer's disease. Dr. Susan McAlester genetically engineers three Mako Sharks so that that the brain tissue to acquire more tissue to help find a cure, however this also makes the shark more intelligent then before. After a accident during one of the tissues extractions the sharks find out a way to escape and attack the humans inside. Also the accident is now causing the facility to sick and letting the water rise allowing the sharks to attack the scientist easily. The crew and scientist most escape and not let the sharks reach open water to breed.