Captain Thorne Sherman is delivering a shipment of supplies to isolated island where a scientist, his daughter and the assistants are conducting experience. They unfortunately have created a new breed of large man eating shrew that have eaten all the small creatures of the island and now have their sights on the humans. Sherman and the rest of the people try to figure out a way to escape the Killer Shrews.

    The movie also appeared on the show Mystery Science Theater 3000, episode 407.