Sissy Hankshaw is born with thumbs that are larger than those of the average person. Missy sees her thumbs, as it says under the definition of thumbs, as greater freedom of movement. She uses them to hitchhike all over the country because she believes that is what she was born to do. A gay man named the Countess hired her as a feminine hygiene model when she was in her late teens. Later he calls on her to shoot a commercial at the beauty ranch he runs. When she arrives, she finds all the workers have practically taken over the ranch and become cowgirls. She makes friends with the sort of leader Bonanza Jellybean and helps to take over the ranch. The cowgirls have peyote visions and try to save whooping cranes, and at the same time Missy and Jellybean fall in love.