Noted surgeon Richard Kimble is wrongfully accused, tried and convicted for the brutal murder of his wife. A failed escape attempt by other prisoners gives Kimble his opportunity to escape execution. The only option and purpose he has left is to discover who really murdered his wife and clear his name. On his trail is persistent US Marshal Samuel Gerard who slowly comes to believe that the original case might not be as clear cut as was first believed.And finds a one-armed man involved in the murder. Based on the TV series from 1963-1967.