Just how much trouble can two guys get into while trying to catch some fish? Joe Waters (Joe Pesci) and Gus Green (Danny Glover) are two guys from New Jersey who've known each other since childhood; they've always been friends, and they've always been inept to the point of posing a threat to life and limb (early on in the proceedings, we get to watch them blow up a factory by accident). Joe and Gus are avid fishermen, and as luck would have it, they win a trip to the Everglades to do some serious angling. They hitch their boat trailer to Joe's 1968 Plymouth and hit the road to Florida, but they run afoul of a con man named Dekker Massey (Nick Brimble), who quickly relieves Joe of his automobile. Not about to let the loss of their wheels stop them, Joe and Gus try to hitch a ride, and they get picked up by a pair of beautiful women, Rita (Rosanna Arquette) and Angie (Lynn Whitfield), who are also headed South. It seems that Dekker conned Rita's mom out of much of her valuables, and they're looking for him in hopes of getting them back; Joe and Gus get roped into helping them out, which leads to a number of misadventures involving guns, treasure maps, boat chases, and hurricanes. Sadly, the production of this comedy had tragic consequences when a stunt performer was killed and two others were seriously injured while filming a jump on a boat ramp.